Best Medicines for Sinus Infection in 2020 – [Top 10 Picks Reviews]


Health is essential for every person to live a happy life, but nowadays, there are lots of diseases that occur due to some discomfort factors. To overcome this, we have used instant medication and therapies to get rid of the problems. In this case, this is one of the medicines to relieve sinus infections.

Most sinus infections last just five to ten days. The sinus symptoms are facial pain, congestion, stuffiness, and lots of drainages. Bacterial sinus infections are much more common, so you need antibiotics. These sinus medicines provide complete relief for your sinus pressure and sinus pain. Here we have reviewed some of the best medication for severe sinusitis.

Best Medicines for Sinus Infection - 10 Products Reviewed

1. Flonase Nasal Spray for Allergy Relief

Flonase Nasal Spray Allergy Medicine is one of the best sinus medicine that reduces sinus and breath problems quickly. This allergy medicine provides excellent relief for nasal congestion, watery eyes, itchy nose, runny nose, and sneezing.


  • No rebound effect
  • 24 hours relief for your sinus problem
  • Treats the allergens before they enter the body
  • Perfect for indoor and outdoor allergies

Flonase Nasal Allergy Spray is the number 1 sinus infection medicine, and the doctors also recommend this allergy medicine. This sinus medicine acts as multiple inflammatory substances, and it reduces histamine.

Flonase Nasal Spray Allergy Medicine gives complete allergy relief compared to other allergy tablets. This medicine helps to block six allergic substances, but other sinus allergy tablets block histamine only. It provides 24 hours of relief for both indoor and outdoor allergies like dust, mold, pet allergy, grasses, and vender.


  • Easy to use
  • Non-drowsy
  • Reduce the common cold


  • Produce side effect

The full prescription strength nasal spray gives non-drowsy. Flonase nasal spray reduces dust mite allergens that enter the nasal passages. It provides complete relief for your sinus problem within a few days, and you can use these daily ones.

The active components of this nasal spray are fluticasone propionate. Before going to bed, you can use this nasal spray, which supports to rinse your nasal blockage. This sinus nasal spray reduces the sinus pressure, sinus headaches, and other sinus congestion, and it also reduces the swelling.

2. Eu Natural Sinus Infection Medicine

Eu Natural medicine is the best pain reliever for Sinus & Lungs Breathing so that you can breathe quickly and deeply in a natural way. It also maintains nasal passages for open and clear at any condition or season. This medicine is a mix of full-spectrum herbal extracts that offer respiratory relief, reduce congestion, sinus pressure, tight chest, migraine issues, and discomfort.


  • Reduces the sinus issues in 3 to 6 weeks
  • Helps to increase the immune response
  • Made with full-spectrum natural herbal extracts
  • Effectively reduce the sinus infection
  • Bronchial wellness

Eu Natural medicine made with some natural products or ingredients like butterbur, nettle leaf, Boswellia, and Quercetin that support a healthy immune response and promote balanced histamine levels. This combination will help to improve your sinus problem from inside.

This sinus medicine provides a seasonal strength to your nose, respiratory, eyes, and immune system; every capsule gives excellent strength and potency in your health.


  • Open and clear airways
  • Nasal support
  • It worked to decrease asthma


  • Little bit expensive

These capsules come with cGMP certified and tested in the laboratory to assure FDA standards and contaminant-free of the tablets. Eu Natural is 100% vegetarian and easy to take soft capsules, totally free of fillers, binders, and artificial ingredients. This sinus infection medicine includes herbs, minerals, and vitamins, which are formulated to increase your health.

The kids and adults can also use this medicine, and it doesn’t produce any side effects. You can use this medicine twice a day with eight-ounce water and food, and it reduces the sinus problem in 3 to 6 weeks.

3. Zyrtec 24 Hour Allergy Relief Tablets

Zyrtec 24 Hour Allergy Relief Tablets gives powerful relief for your sinus allergy symptoms. It also relieves indoor and outdoor allergy symptoms. You can take this sinus allergy relief tablets while begin to work hard for one hour and retake it for the next day when you begin to work two times harder.


  • 24 hours of pain relief tablet
  • Suitable for toddler and adults
  • Improves indoor and outdoor allergies
  • Reduces the nasal and sinus congestion

These prescription allergy tablets quickly relieve the sinus problem and provide all-day allergy relief. These allergy tablets treat watery eyes, itchy nose, sneezing, runny nose, and throat.

This sinus infection medicine provides a complete 24 relief for your sinus problem so that you can feel better and sleep comfortably at night. The antihistamine contains 10mg cetirizine hydrochloride in all anti-allergy tablets. This anti-allergy tablet efficiently handles infection allergies like pet dander, dust, and mold.


  • Excellent for allergy sufferers
  • Simple to swallow
  • Reduce sneezing


  • Produce little side effects

It also treats outdoor allergies like weeds, pollen, and grasses and reduces the sinus symptoms quickly. The antihistamines are effective allergy relief tablets for fever and other respiratory allergies.

The decongestant reduces both sinuses as well as nasal congestion, and also it reduces narrowing swollen membranes. Their many allergens are airborne and quickly contact your eyes to reduce the water eyes and itchy problem.

Sometimes these allergens are entering into the nose that causes the membrane to swell and push the liquid out of the small blood vessels. This sinus infection medicine is suitable for six years of age and older, which gives practical and powerful relief in a single dose.

4. Benadryl Ultratabs Antihistamine Allergy Relief

The Benadryl Ultratabs reduces the sinus pressure and sinus headaches quickly. It contains 25 mg of the antihistamine diphenhydramine HCl in each tablet. It temporarily provides allergy relief for runny nose, itchy nose, sneezing, itchy throat, and watery eyes.


  • Each tablet contain 25 mg antihistamine diphenhydramine HCl
  • Reduce cold and allergy symptoms
  • Multi-symptom allergy relief
  • Improves breathing problems

It also offers temporary relief for cold symptoms. These allergy tablets come with two different sizes, such as ultra and small size. The ultra tablets provide effective allergy relief from the upper respiratory, and small size tablets to reduce the common cold symptoms quickly. The active ingredient of the Benadryl Allergy tablets is diphenhydramine HCl, which gives relief for common cold symptoms and allergy symptoms.

The active ingredients provide soothing relief from sinuses and help you breathe more effectively. This allergy tablet helps to reduce multi-symptoms allergies, and it improves breathing problems like emphysema and chronic bronchitis.


  • Easy to Swallow
  • Convenient and cheap
  • Perfect for Dog Allergies


  • Not suitable for everyone

The inactive ingredient is croscarmellose sodium, polyethylene glycol, polysorbate 80, titanium dioxide, etc. This infection medicine is the best solution for your sinus problem. Using this tablet, you can get a peaceful night’s sleep. Children and adults mainly used this to get rid of their sinus infections. You can take one capsule, which gives 24 hours of pain relief.

Benadryl Antihistamine Allergy Relief tablets improve your sinus pressure, sinus congestion, flu, cold, and sinus headaches. You can store the medicine at 59° to 77°F in a dry place.

5. Kirkland Brand Sinus Allergy Medicine

Kirkland Brand Allergy Medicine has similar characteristics of Benadryl Allergy Relief medicine. This medicine provides excellent relief for indoor and outdoor allergies like dust, mold, pollen, grasses, and ragweed. It reduces massive sneezing problems and itchy watery eyes congestion.


  • Quality Allergy Relief tablet
  • Excellent for dog allergies
  • Contains Diphenhydramine HCl 25mg
  • Reduce the natural chemical histamine effects

Use this allergy relief medicine for both occasional and seasonal allergies, and it provides excellent relief for various types of sinus allergies. This allergy medicine decreases all the sinus allergies effectively and helps to deal with the allergy symptoms of the sneezing nose, itchy, and watery eyes.

This sinus allergy medicine reduces the sinus pressure and sinus congestion quickly. It reduces the pain within 20minutes so you can swallow this allergy medicine easily.


  • Used to take this all the time
  • Quality Allergy Relief
  • Reliable antihistamine


  • Not suitable for everyone

It provides 24 hours relief for sinus problems in your body. It reduces the runny nose hives and itchy throat using the Aller-Tec Antihistamine. Kirkland Allergy Tablets active component is Diphenhydramine 25mg.

Simple to swallow antihistamine that reduces sneezing, runny nose, itchy throat, watery eyes, and other allergy symptoms. The adults, children 12 years and older, used this sinus medicine. You can store this medicine at 25ºC in dry places. These Antihistamines tablets temporarily decrease the natural chemical histamine effects in your body.

6. Medique Sinus & Pain Pressure Tablets

Medique Sinus & Pain Pressure Tablets provide complete relief for sinus pressure, sinus headaches, and frequent cold problems. Each Medique sinus pain pressure tablets contain 500 mg Acetaminophen and 5 mg Phenylephrine HCl.

This tablet gives fast relief for sinus pressure, nasal congestion, nasal secretions, common cold, and upper respiratory. It also relieves the sinus pain, aches related to colds and flu.


  • Unit dose packets
  • Simple to swallow
  • Film-coated tablets
  • Relieves headache, sinus pain and sinus congestion

Acetaminophen is a fever reducer and pain reliever which is used for many sinus problems such as muscle aches and headache. The cold can cause aching in your body so that you can be tired in every activity or work. You can use this tablet daily to reduces your pain so that you can feel better and relaxed sleep at night.

Phenylephrine provides temporary relief for watery eyes, runny nose, ear, and sinus symptoms produced by flu, allergies, sinusitis, bronchitis, common cold, and other breathing illness.


  • Cheap and convenient
  • Excellent headache medicine
  • Highly recommended for all


  • A tiny dose of decongestant

This sinus infection medicine minimizes the swelling in your ears and nose; It reduces the discomfort, and you can breathe easily. You can swallow this tablet easily, and it comes in a unit dose.

This sinus pain and pressure tablet come with dual-layer foil packets and tamper-evident. After 30 min of taking this tablet, you can feel better relief for sinus pressure pain.

7. Tylenol Sinus Allergy Medicine

Tylenol Sinus Allergy Medicine delivers fast relief for sinus symptoms, headache, and sinus pain. It provides complete relief from hay fever, common cold, and other respiratory allergies. Each Tylenol sinus allergy medicine contains 325 mg acetaminophen, 5 mg phenylephrine HCl.


  • Helps decongest sinus openings and passages
  • Promotes sinus drainage
  • Helps clear nasal passages
  • Temporarily reduces fever

It provides temporary relief for pain and also reduces fever. The nose decongestant is supported to clear the nasal passages. This medicine comes with non-drowsy, which offers effective daytime sinus symptom relief and encourages the sinus drainage.

This medicine used to treat the decongest sinus passages and sinus openings.


  • Inexpensive
  • Reduces sinus headaches
  • Excellent sinus medicine


  • Doesn't clear the nasal passage

The doctors recommended sinus pain relief products, and these allergy relief medicines are perfect for adults and children twelve years. You can use this medicine for getting 4 hours of complete relief from the sinus problem. You can use this medicine for both indoor and outdoor sinus allergy problems like pet allergy, grasses, pollen, dust, and mold.

An air filtration system, dehumidifier, and HEPA filters are aids to enhance the air quality in your circumference, thus you can control the mold growth. The sinus people feel hard to breathe, sinus pressure, the stain of the lips, and sinus congestion. This Tylenol sinus allergy medicine improves all these problems.

8. GoodSense Nasal Decongestant

GoodSense Nasal Decongestant is the temporary pain reliever for sinus pressure and sinus congestion, and it also relieves the nasal congestion like the common cold, fever, and other respiratory allergies. This sinus infection medicine is made with high-quality and high-grade natural ingredients.


  • 24 hours of pain relief tablet for all sinus problem
  • Suitable for kids and adults
  • Improves flu and common cold allergies
  • It also reduces fever and sinus pressure

This allergy tablet contains 10mg phenylephrine Hcl in each capsule. The phenylephrine Hcl is the active ingredient in these capsules. This medicine gives non-drowsy relief and maximum strength for sinus and nasal congestion, migraine headaches, and sinus pressure.

The cold includes sneezing, sore throat, coughing, and runny nose. These symptoms can continue for up to two weeks. The cold produces 200 common diseases, and the rhinovirus mostly produces the common cold.


  • Relieves sinus drainage
  • Inexpensive
  • Perfect for air weather


  • Phenylephrine does not work

The influenza viruses affect the throat, lungs, and nose, and it can produce mild to severe illness. The sinus people are difficult to breathe, discoloration of the lips, and sinus congestion, but this medicine improves all problems. Use the natural saline sprays for your nose before the bed, which helps to clean your nasal blockage.

Antihistamine medicine is quick to relieve sinus infections, and it also reduces allergy symptoms. This cold medicine provides 24 hours of relief for the sinus problem.

9. Motrin Ibuprofen 200mg Tablets for Fever

Motrin IB tablets help to provide effective relief from sinus pressure, minor aches, sinus headaches, and pains. This tablet easily controls your sinus pain and brings a better feel.

This sinus infection medicine temporarily decreases fever and gives pain relief for backaches, toothaches, menstrual cramps, and the common cold. This infection medicine is made with natural ingredients that provide excellent pain relief.


  • Improve Headache, back pain
  • Gives complete pain relief
  • It has many sizes and shapes
  • Blood pressure people and adults use
  • Reliable pain relief

It comes with many doses such as 24 CT, 50 CT, 100 CT, 225 CT, and 300 CT that provide complete relief to your sinus problem. You can take one tablet that gives 4 to 6 hours of pain relief for your sinus problem.

The 12 years of children and older people also used this medicine. This cold sinus medicine gives a seasonal strength to your eyes, nose, immune system, and respiratory.


  • Quality pain reliever
  • Easy to use
  • Reduce runny nose


  • Side effect

Every tablet provides excellent power and potency in your body or health. You can store this tablet in 20 to 25 degrees C; it will relieve your back pain, headaches, so that you can feel better and comfortable sleep at night.

This sinus medicine doesn’t cause any side effects, and it is non-toxic and latex-free. The natural ingredients give calming relief from sinuses and assists you to breathe more efficiently.

10. Amazon Basic Care sinus infection medicine

Low immunity people can be affected easily by allergies. Amazon Basic Care sinus medicine supports treating seasonal diseases so that you can feel better relief from allergy or sinus symptoms.

This medicine is FDA Certified and assists in relief from allergy diseases like sneezing, irritated eyes, itchy nose, throat, sinus pressure, runny nose, and nasal congestion.


  • Each capsule include 10 mg cetirizine hydrochloride
  • 24 hours of allergy relief
  • Used indoor and outdoor allergies
  • Original prescription strength

The active ingredients of this medicine are cetirizine hydrochloride and the antihistamine. The basic care medicine is used for indoor and outdoor sinus allergies.

This allergy medicine provides 24 hours of pain relief and temporarily gives relief for fever and other respiratory allergies. Organic technology reduces the toxic synthetics, so the basic care sinus medicine is healthier.


  • Effective allergy treatment
  • Reduce sneezing, itchy nose
  • Excellent allergy tablet


  • Not effective

You can use this tablet to take any time, any place, or anywhere. The adults and children use this medicine that reduces allergies like flu, cold, sleeplessness, stress, and more.

These sinus allergy medicines come with original prescription strength and not gluten, and it is non-drowsy. 

Types of Sinus Medicines

The combination of sinus infection medicine is used for the temporary treatment for the symptoms of sinus like flu, cold, allergies, and other breathing problems.


The Decongestants medicines are helping you to relieve a stuffy nose. Stuffy nose is the most irritating problem triggered by the inflammation in the blood vessels of the sinus. Due to the acute upper respiratory infection, the blood vessels can be disturbed because of cold and sinus infection. Decongestants medicine is helping to relieve this problem. 


Acetaminophen medicines are the most commonly used sinus medicine; it is a non-aspirin pain reliever and the fever reducer, which helps to reduce the pain.


The Antihistamines medicines are designed for resisting the action of histamine; this is one of the chemicals that is generated in the body for allergic reactions like itches in eyes, nose, throat, and watery eye and running nose problem. Also, these medicines help to reduce nasal stuffiness and mucus production. If you have any allergies due to the sinus, your healthcare provider refers to add this medicine for your treatment. 


Antibiotic medicines are specially designed for the bacteria infection; in some cases of sinus, that will be caused by the bacteria infection. It is difficult to treat the bacteria-infected person because the bacterias are expanded in the warm, moist, and dark area of the sinus spaces. Usually, these infections are responding to antibiotic treatment, whatever, you have to continue the infection treatment for one to three weeks or more. The antibiotic treatments are based on allergies, symptoms, drugs, and your previous medicines. 

Sometimes your healthcare provider will collect the mucus from the nose and send it to the laboratory to check the bacteria infection. This test will also help to choose the antibiotic for bacteria infections. Using antibiotics leads to bacterial resistance and side effects, so you have to use the antibiotics carefully and thoughtfully. 


We hope that now you have a better idea of shopping for sinus infection medicine. There is a lot of high-quality sinus medicine available in the markets. If you would like to purchase the medicine for your sinus problem, we give the best medicine list for the best start of the search. 

The best medicine helps to provide complete relief for your sinus problem. We hope now you have all the information that you need for the sinus medicine purchase.